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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K1
All Species:
27.27
Human Site:
S72
Identified Species:
46.15
UniProt:
Q02750
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02750
NP_002746.1
393
43439
S72
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
S72
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
Rhesus Macaque
Macaca mulatta
XP_001110225
393
43444
S72
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31938
393
43456
S72
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
Rat
Rattus norvegicus
Q01986
393
43447
S72
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
R93
D
S
P
R
A
Q
T
R
I
L
P
N
S
H
L
Chicken
Gallus gallus
Q90891
398
44059
S74
D
D
D
F
E
R
I
S
E
L
G
A
G
N
G
Frog
Xenopus laevis
Q05116
395
43724
S72
D
D
D
F
E
K
V
S
E
L
G
A
G
N
G
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
G84
A
D
D
L
E
Q
I
G
E
L
G
R
G
A
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
G91
D
E
D
L
E
K
L
G
E
L
G
S
G
N
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
G77
E
D
M
L
Q
T
E
G
E
L
G
H
G
N
G
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
K91
N
D
D
F
E
V
L
K
E
L
G
A
G
N
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
K74
L
S
D
L
D
M
V
K
V
I
G
K
G
S
S
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
D364
L
D
E
L
E
F
L
D
E
L
G
H
G
N
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
98.9
99.2
N.A.
73
81.6
91.9
33.3
N.A.
62.3
N.A.
52.4
64.8
Protein Similarity:
100
99.2
100
N.A.
N.A.
99.4
99.7
N.A.
77.8
88.9
96.1
51.4
N.A.
77.7
N.A.
69.2
75.7
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
13.3
93.3
93.3
53.3
N.A.
66.6
N.A.
46.6
73.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
26.6
100
100
60
N.A.
86.6
N.A.
60
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.3
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.4
33.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
0
0
0
58
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
65
79
79
0
8
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
8
8
8
0
79
0
8
0
86
0
0
0
0
0
0
% E
% Phe:
0
0
0
58
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
22
0
0
93
0
93
0
72
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
15
0
8
0
% H
% Ile:
0
0
0
0
0
0
50
0
8
8
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
50
0
15
0
0
0
8
0
0
0
% K
% Leu:
15
0
0
36
0
0
22
0
0
93
0
0
0
0
8
% L
% Met:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
8
0
79
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
8
15
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
8
0
8
0
8
0
0
0
8
0
0
0
% R
% Ser:
0
15
0
0
0
0
0
50
0
0
0
8
8
8
8
% S
% Thr:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
15
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _